Antihyperlipidemic effects of Citrus sinensis, Citrus paradisi, and their combinations
Identifieur interne : 000331 ( Main/Exploration ); précédent : 000330; suivant : 000332Antihyperlipidemic effects of Citrus sinensis, Citrus paradisi, and their combinations
Auteurs : Neelam Mallick [Pakistan] ; Rafeeq Alam Khan [Pakistan]Source :
- Journal of Pharmacy & Bioallied Sciences [ 0976-4879 ] ; 2016.
Abstract
Hyperlipidemia, extensively contributes in the progression of coronary heart diseases and atherosclerosis, but may be managed through alterations in the nutritional pattern. Several studies show that diet rich in polyphenols and antioxidants have antiatherogenic effects.
All rats were divided into 11 groups each comprising 10 animals: Normal control group and hyperlipidemic control.
Cholesterol, triglycerides (TGs), and low-density lipoprotein (LDL) were decreased at all the three doses of
Results suggest that
Url:
DOI: 10.4103/0975-7406.171727
PubMed: 27134462
PubMed Central: 4832900
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antihyperlipidemic effects of <italic>Citrus sinensis</italic>, <italic>Citrus paradisi</italic>, and their combinations</title><author><name sortKey="Mallick, Neelam" sort="Mallick, Neelam" uniqKey="Mallick N" first="Neelam" last="Mallick">Neelam Mallick</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi 75270, Pakistan</nlm:aff><country xml:lang="fr">Pakistan</country><wicri:regionArea>Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi 75270</wicri:regionArea><wicri:noRegion>Karachi 75270</wicri:noRegion></affiliation></author><author><name sortKey="Khan, Rafeeq Alam" sort="Khan, Rafeeq Alam" uniqKey="Khan R" first="Rafeeq Alam" last="Khan">Rafeeq Alam Khan</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi 75270, Pakistan</nlm:aff><country xml:lang="fr">Pakistan</country><wicri:regionArea>Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi 75270</wicri:regionArea><wicri:noRegion>Karachi 75270</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27134462</idno><idno type="pmc">4832900</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832900</idno><idno type="RBID">PMC:4832900</idno><idno type="doi">10.4103/0975-7406.171727</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000358</idno><idno type="wicri:Area/Pmc/Curation">000357</idno><idno type="wicri:Area/Pmc/Checkpoint">000265</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000095</idno><idno type="wicri:Area/PubMed/Curation">000095</idno><idno type="wicri:Area/PubMed/Checkpoint">000095</idno><idno type="wicri:Area/Ncbi/Merge">002009</idno><idno type="wicri:Area/Ncbi/Curation">002009</idno><idno type="wicri:Area/Ncbi/Checkpoint">002009</idno><idno type="wicri:doubleKey">0976-4879:2016:Mallick N:antihyperlipidemic:effects:of</idno><idno type="wicri:Area/Main/Merge">000331</idno><idno type="wicri:Area/Main/Curation">000331</idno><idno type="wicri:Area/Main/Exploration">000331</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Antihyperlipidemic effects of <italic>Citrus sinensis</italic>, <italic>Citrus paradisi</italic>, and their combinations</title><author><name sortKey="Mallick, Neelam" sort="Mallick, Neelam" uniqKey="Mallick N" first="Neelam" last="Mallick">Neelam Mallick</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi 75270, Pakistan</nlm:aff><country xml:lang="fr">Pakistan</country><wicri:regionArea>Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi 75270</wicri:regionArea><wicri:noRegion>Karachi 75270</wicri:noRegion></affiliation></author><author><name sortKey="Khan, Rafeeq Alam" sort="Khan, Rafeeq Alam" uniqKey="Khan R" first="Rafeeq Alam" last="Khan">Rafeeq Alam Khan</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi 75270, Pakistan</nlm:aff><country xml:lang="fr">Pakistan</country><wicri:regionArea>Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi 75270</wicri:regionArea><wicri:noRegion>Karachi 75270</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of Pharmacy & Bioallied Sciences</title><idno type="ISSN">0976-4879</idno><idno type="eISSN">0975-7406</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Objective:</title><p>Hyperlipidemia, extensively contributes in the progression of coronary heart diseases and atherosclerosis, but may be managed through alterations in the nutritional pattern. Several studies show that diet rich in polyphenols and antioxidants have antiatherogenic effects. <italic>Citrus sinensis</italic> and <italic>Citrus paradisi</italic> are widely known for health benefits and have found to produce antioxidant, anti-inflammatory, and hypolipidemic effects, hence current research was planned to determine the hypolipidemic effects of <italic>C. sinensis</italic> and <italic>C. paradisi</italic> in rats receiving diet rich in cholesterol.</p></sec><sec id="st2"><title>Materials and Methods:</title><p>All rats were divided into 11 groups each comprising 10 animals: Normal control group and hyperlipidemic control. <italic>C. sinensis</italic> treated three groups, <italic>C. paradisi</italic> treated three groups, <italic>C. sinensis</italic> and <italic>C. paradisi</italic> combination treated two groups, and group treated atorvastatin. All rats in the respective groups were treated orally with sterile water, juices, and standard drug for 8 weeks and lipid profile was estimated at the end of dosing.</p></sec><sec id="st3"><title>Results:</title><p>Cholesterol, triglycerides (TGs), and low-density lipoprotein (LDL) were decreased at all the three doses of <italic>C. sinensis</italic> and <italic>C. paradisi</italic> but rise in high-density lipoprotein (HDL) was only significant at 8 ml/kg, and 0.3 ml/kg, respectively. Animals received the combination doses of <italic>C. sinensis</italic> and <italic>C. paradisi</italic> also showed a highly significant fall in cholesterol, LDL, and TGs, however HDL level was significantly elevated by SPJ-2 combination.</p></sec><sec id="st4"><title>Conclusion:</title><p>Results suggest that <italic>C. sinensis</italic> and <italic>C. paradisi</italic> possess antihyperlipidemic activity due to phytochemicals and other essential nutrients, hence may serve as cardioprotective by preventing thrombosis.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kanakavalli, K" uniqKey="Kanakavalli K">K Kanakavalli</name></author><author><name sortKey="Thillaivanan, S" uniqKey="Thillaivanan S">S Thillaivanan</name></author><author><name sortKey="Parthiban, P" uniqKey="Parthiban P">P Parthiban</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Wald, Nj" 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Chan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grogan, Wm" uniqKey="Grogan W">WM Grogan</name></author><author><name sortKey="Bailey, Ml" uniqKey="Bailey M">ML Bailey</name></author><author><name sortKey="Heuman, Dm" uniqKey="Heuman D">DM Heuman</name></author><author><name sortKey="Vlahcevic, Zr" uniqKey="Vlahcevic Z">ZR Vlahcevic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mortensen, A" uniqKey="Mortensen A">A Mortensen</name></author><author><name sortKey="Breinholt, V" uniqKey="Breinholt V">V Breinholt</name></author><author><name sortKey="Dalsgaard, T" uniqKey="Dalsgaard T">T Dalsgaard</name></author><author><name sortKey="Frandsen, H" uniqKey="Frandsen H">H Frandsen</name></author><author><name sortKey="Lauridsen, St" uniqKey="Lauridsen S">ST Lauridsen</name></author><author><name sortKey="Laigaard, J" uniqKey="Laigaard J">J Laigaard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nielsen, Lb" uniqKey="Nielsen L">LB Nielsen</name></author><author><name sortKey="Stender, S" uniqKey="Stender S">S Stender</name></author><author><name sortKey="Kjeldsen, K" uniqKey="Kjeldsen K">K Kjeldsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zeiher, Am" uniqKey="Zeiher A">AM Zeiher</name></author><author><name sortKey="Drexler, H" uniqKey="Drexler H">H Drexler</name></author><author><name sortKey="Saurbier, B" uniqKey="Saurbier B">B Saurbier</name></author><author><name sortKey="Just, H" uniqKey="Just H">H Just</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Quyyumi, A" uniqKey="Quyyumi A">A Quyyumi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anoosh, E" uniqKey="Anoosh E">E Anoosh</name></author><author><name sortKey="Mojtaba, E" uniqKey="Mojtaba E">E Mojtaba</name></author><author><name sortKey="Fatemeh, S" uniqKey="Fatemeh S">S Fatemeh</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Pakistan</li></country></list><tree><country name="Pakistan"><noRegion><name sortKey="Mallick, Neelam" sort="Mallick, Neelam" uniqKey="Mallick N" first="Neelam" last="Mallick">Neelam Mallick</name></noRegion><name sortKey="Khan, Rafeeq Alam" sort="Khan, Rafeeq Alam" uniqKey="Khan R" first="Rafeeq Alam" last="Khan">Rafeeq Alam Khan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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